6-[(2-methylpropan-2-yl)oxycarbonyl]-6-azaspiro[2.5]octane-2-carboxylic acid
6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid(SALTDATA: FREE)
CAS: 871727-05-8
Molecular Formula: C13H21NO4
6-[(2-methylpropan-2-yl)oxycarbonyl]-6-azaspiro[2.5]octane-2-carboxylic acid - Names and Identifiers
6-[(2-methylpropan-2-yl)oxycarbonyl]-6-azaspiro[2.5]octane-2-carboxylic acid - Physico-chemical Properties
| Molecular Formula | C13H21NO4 |
| Molar Mass | 255.31 |
| Density | 1.20±0.1 g/cm3(Predicted) |
| Boling Point | 392.1±35.0 °C(Predicted) |
| pKa | 4.71±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
6-[(2-methylpropan-2-yl)oxycarbonyl]-6-azaspiro[2.5]octane-2-carboxylic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36 - Irritating to the eyes |
| Safety Description | 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
6-[(2-methylpropan-2-yl)oxycarbonyl]-6-azaspiro[2.5]octane-2-carboxylic acid - Reference Information
| application | 6-BOC-6-azanolo [2.5] octane -1-formic acid is an important pharmaceutical intermediate and an important synthetic raw material for many drugs and auxiliaries. Used for the preparation of tyrosine kinases and some protein kinase inhibitors. |
| preparation | thermometer, dropping funnel and condenser tube are respectively installed on a 100ml dry three-diameter round bottom flask, 6-azelo [2.5] octane -1-carboxylic acid and acetone are sequentially added, and stirred at 35 ℃ for 30 minutes.. The reaction system is cooled to -10 ℃ in an ice salt bath, sodium hydroxide aqueous solution is added and stirred. When the reaction temperature drops to -5 ℃, di-tert-butyl dicarbonate is slowly added, and the temperature of the system is controlled to 0 ℃. After dropping for about 40 minutes, continue stirring for 1 hour. Wash the reaction solution to neutral, dry with anhydrous magnesium sulfate, evaporate the solvent, and recrystallize the solid with ethyl acetate /petroleum ether to obtain the product 6-(tert-butoxycarbonyl)-6-Azasol [2.5] octane -1-carboxylic acid. |
Last Update：2024-04-10 22:29:15
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Product Name: 6-(tert-butoxycarbonyl)-6-azaspiro[2.5]octane-1-carboxylic acid(SALTDATA: FREE) Visit Supplier Webpage Request for quotation
CAS: 871727-05-8
Tel: 18301782025
Email: 3008007409@qq.com
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CAS: 871727-05-8
Tel: 18301782025
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View History
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